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Genetics and Genetic Engineering

General data

Course ID: 1400-114GEN Erasmus code / ISCED: 13.1 / (unknown)
Course title: Genetics and Genetic Engineering Name in Polish: Genetyka z inżynierią genetyczną
Organizational unit: Faculty of Biology
Course groups: Requisite courses for first-year students of Biology
Requisite subjects for first-year students of Biotechnology
ECTS credit allocation (and other scores): 8.00 OR 6.00 (depends on study program)
view allocation of credits
Language: Polish
Main fields of studies for MISMaP:

biotechnology

Type of course:

obligatory courses

Short description:

In this course students become acquainted with the classic genetics and molecular genetics.

Full description:

Lecture

Classical genetics: basic concepts and terminology. Methods of genetic analysis. DNA as the genetic material. Structure and replication of DNA. Genetic code. Structure and regulation of expression of prokaryotic gene. Structure, expression and regulation of eukaryotic gene. Genetic basis of differentiation. Genetics and cancer. Genetic basis of immunity. Methods of genetic engineering. Genetic basis of modern biotechnology. Genomics and proteomics. Genes and evolution.

Practicals

Gene expression in Prokaryotes: Mutations, mutagenesis. Genetic code. Prokaryotic gene structure. Operons. Regulation of gene expression in bacteria.

Genetic analysis in Eucaryotes: Mendelian genetics. Complementation, recombination and other genetic tests in Drosophila melanogaster, Aspergillus nidulans and Saccharomyces cerevisiae. Eukaryotic gene structure and expression.

Genetic engineering: PCR. Recombinant DNA technology. Restriction maps. Genomic and cDNA libraries. DNA sequence analysis. Yeast S. cerevisiae as a host for cloning. Gene disruption in yeast. Basic hybridization techniques. Heterologous expression. Reporter genes.

Bibliography:

Concepts of Genetics. W. S. Klug, M. R Cummings, C. Spencer. 2006 or later

Genes VII. Benjamin Lewin. 2000 or later

Genomes 2. T. A. Brown. 2002

Learning outcomes:

KNOWLEDGE

- Knows the basic concepts of genetic information, genetic material, the genetic code, genotype and phenotype

- Knows the molecular mechanisms underlying such phenomena as dominance and co-dominance, loss and gain of gene function

- Knows the mechanisms for the transmission of genetic information

- Knows mechanisms of prokaryotic and eukaryotic gene expression

- Knows the basics of design and implementation of genetic modifications

- Knows the basic molecular biology techniques used in genetic engineering

- Understands the importance of experimental work and is able to describe the importance of molecular analyses in genetic

- Knows the outline of the evolution of genetic information and evidence for evolution contained in the genomes of living organisms.

ABILITIES

- Analyzes the flow of genetic information in the living organisms

- Properly uses the basic concepts of genetics, especially genetic information, genetic material, genetic code, genotype and phenotype

- Examines the relationship between changes in genotype and resulting changes in phenotype

- Analyzes the genetic interactions, and can indicate their significance for systems biology

- Compares the mechanisms of prokaryotic and eukaryotic gene expression

- Is able to design a simple experiment leading to cloning selected DNA fragment

- Is able to choose the appropriate technique to study basic molecular processes

- Interprets the experimental results of classical, molecular and medical genetics

SOCIAL AWARENESS

- Formulates rational and modern science-based arguments in the controversial issues relating to the consequences of genetic engineering techniques for the environment and human health. - Indicates the importance of genetics and molecular biology to medicine and other areas of human activity.

- Understands the need to inform the public about the new achievements of genetics and genetic engineering, and can explain them in an understandable way

- Shows caution and criticism in the reception and interpretation of information in the field of genetics and genetic engineering available in the mass media.

Assessment methods and assessment criteria:

Written examination composed of two parts: a multiple choice test and a series of open questions. Exams are graded based on the total points obtained from both parts, minimum is 50%+1 point.

Practical placement:

No

Classes in period "Summer semester 2021/22" (in progress)

Time span: 2022-02-21 - 2022-06-15
Choosen plan division:


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Type of class: Class, 60 hours more information
Lecture, 30 hours more information
Coordinators: Katarzyna Tońska
Group instructors: Łukasz Borowski, Agnieszka Dzikowska, Paweł Golik, Anna Golisz, Agnieszka Gozdek, Dorota Hoffman-Zacharska, Magdalena Kaliszewska, Michał Koper, Konrad Kosicki, Karolina Łabędzka-Dmoch, Seweryn Mroczek, Robert Mysłajek, Agnieszka Piotrowska-Nowak, Rafał Tomecki, Katarzyna Tońska, Tomasz Wilanowski, Monika Zakrzewska-Płaczek
Students list: (inaccessible to you)
Examination: Course - Examination
Class - Grading
Lecture - Examination
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