Bioorganic Chemistry

General data

Course ID:	1100-1BB23
Erasmus code / ISCED:	13.301 Kod klasyfikacyjny przedmiotu składa się z trzech do pięciu cyfr, przy czym trzy pierwsze oznaczają klasyfikację dziedziny wg. Listy kodów dziedzin obowiązującej w programie Socrates/Erasmus, czwarta (dotąd na ogół 0) – ewentualne uszczegółowienie informacji o dyscyplinie, piąta – stopień zaawansowania przedmiotu ustalony na podstawie roku studiów, dla którego przedmiot jest przeznaczony. / (0531) Chemistry The ISCED (International Standard Classification of Education) code has been designed by UNESCO.
Course title:	Bioorganic Chemistry
Name in Polish:	Chemia bioorganiczna
Organizational unit:	Faculty of Physics
Course groups:
ECTS credit allocation (and other scores):	(not available) Basic information on ECTS credits allocation principles: the annual hourly workload of the student’s work required to achieve the expected learning outcomes for a given stage is 1500-1800h, corresponding to 60 ECTS; the student’s weekly hourly workload is 45 h; 1 ECTS point corresponds to 25-30 hours of student work needed to achieve the assumed learning outcomes; weekly student workload necessary to achieve the assumed learning outcomes allows to obtain 1.5 ECTS; work required to pass the course, which has been assigned 3 ECTS, constitutes 10% of the semester student load. view allocation of credits
Language:	Polish
Short description:	The course is focused on the synthetic methods, purification, properties and applications of chemical compounds, as well as their synthetic analogues, which play crucial roles in functioning of living cells and organisms.
Full description:	The goal of the lectures in Bioorganic Chemistry is to introduce students to different classes of chemical compounds which play important functions in living organisms. The lectures will answer questions such as: how on the basis of organic chemistry methods is it possible to synthesize such complex biomolecules as peptides or nucleic acids, how to study their structures using modern spectroscopic methods and how their structure influences the biological properties. The knowledge about structure-function relationship of natural compounds is used to design synthetic analogues with improved biological properties. Beside the synthesis of natural compounds, the most important analogues of individual classes will be characterized. The most important applications in the research as well as in biotechnology and medicine will be presented. Program: 1. Amino acids, peptides and proteins - structure and properties 2. Peptide synthesis 3. Enzymes as biocatalysts in chemical reactions. Modified enzymes. 4. Proteins - isolation, purification and modifications. 5. Nucleosides, nucleotides and nucleic acids - structure and functions. 6. Synthesis and properties of nucleosides and nucleotides. Applications in medicine. 7. Modifications of nucleotides within the phosphate moieties. 8. Oligonucleotides DNA and RNA synthesis. Modified analogues of DNA/RNA and their properties: PNA, LNA, PS, MPO etc. 9. Applications of synthetic oligonucleotides: antisense oligonucleotides, ribozymes, aptamers, siRNA. 10. Labelled biomolecules and their applications. 11. Oligosaccharides 12. Alkaloids, terpens, steroids, lipids and dyes - Essential course of organic chemistry is required - Requirements to complete the course: attendance at classes, achieve more than 50% points during exam. Description by Jacek Jemielity, November 2009.
Bibliography:	1. Bioorganic Chemistry - Nucleic Acids. Edited by Sidney M. Hecht, Oxford University Press, 1996. 2. Bioorganic Chemistry - Peptides and Proteins. Edited by Sidney M. Hecht, Oxford University Press, 1998. 3. Biochemistry - Berg, Tymoczko, Stryer. 5th International Edition 4. Current Protocols in Nucleic Acid Chemistry - Edited by Serge L. Beaucage, Wiley and Sons 2008.

This course is not currently offered.

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Copyright by University of Warsaw.