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Molecular biology with genetics, part I

General data

Course ID:	1100-2BB10
Erasmus code / ISCED:	13.4 Kod klasyfikacyjny przedmiotu składa się z trzech do pięciu cyfr, przy czym trzy pierwsze oznaczają klasyfikację dziedziny wg. Listy kodów dziedzin obowiązującej w programie Socrates/Erasmus, czwarta (dotąd na ogół 0) – ewentualne uszczegółowienie informacji o dyscyplinie, piąta – stopień zaawansowania przedmiotu ustalony na podstawie roku studiów, dla którego przedmiot jest przeznaczony. / (0511) Biology The ISCED (International Standard Classification of Education) code has been designed by UNESCO.
Course title:	Molecular biology with genetics, part I
Name in Polish:	Biologia molekularna z genetyką cz. I
Organizational unit:	Faculty of Physics
Course groups:	(in Polish) Biofizyka; przedmioty dla II roku APBM - Molecular Biophysics; 2nd year courses APBM - Molecular Modelling and Bioinformatics; 2nd year courses
ECTS credit allocation (and other scores):	2.00 Basic information on ECTS credits allocation principles: the annual hourly workload of the student’s work required to achieve the expected learning outcomes for a given stage is 1500-1800h, corresponding to 60 ECTS; the student’s weekly hourly workload is 45 h; 1 ECTS point corresponds to 25-30 hours of student work needed to achieve the assumed learning outcomes; weekly student workload necessary to achieve the assumed learning outcomes allows to obtain 1.5 ECTS; work required to pass the course, which has been assigned 3 ECTS, constitutes 10% of the semester student load. view allocation of credits
Language:	Polish
Type of course:	obligatory courses
Mode:	Classroom
Full description:	Program: 1. The genome. Size and structure of the genome: comparison of human genome with genomes of other organisms (bacteria, yeast, plants). Chromatin and its different states; nucleosome and its structure. Chromosome structure. Human karyogram. Telomeric DNA. Genes in the genome; gene families. Genetic organisation of the prokaryotic and eukaryotic genome. Operons. 2. Genomics and its variations (functional, comparison, theoretic, environmental, of individual differences, pharmacogenomics), proteomics, transcriptomics, interactomics, metabolomics, bioinformatics, systems’ biology, knowledge of the above mention names. 3. DNA structure and DNA-binding proteins. B-, A- and Z-DNA. Identification of protein-binding sites in the DNA. Participation of different kinds of protein domains in DNA interaction. 4. Mechanisms of prokaryotic and eukaryotic genome replication. Mutagenesis. Repair mechanisms of DNA. Genome evolution pathways. 5. Initiation, elongation and termination of transcription and their regulation in Prokaryotes and Eukaryotes. Maturation of different RNAs; mechanisms. Pre-mRNA splicing with participation of small nuclear RNAs; spliceosome complexes. “Capping” and polyadenylation. RNA editing. 6. Gene expression regulation during intracellular transport of RNA and proteins via nuclear pore complexes. 7. Mechanisms of protein biosynthesis in prokaryotic and eukaryotic organisms. Post-translational processing of the proteome. 8. Mechanisms of enzymatic RNA degradation. 9.Regulation of gene expression with participation of small non-coding RNA molecules (siRNA, miRNA).
Learning outcomes:	KNOWLEDGE: The student knows the basic problems of a modern molecular biology and genetics. ABILITIES: The student can, without assistance, investigate the latest achievements in the field of the subject. ATTITUDES: The student understands the meaning of problems being a part of the course for medicine and ethics. He / she can develop, without assistance, certain attitudes towards modern research challenges in the field of molecular genetics.
Assessment methods and assessment criteria:	Exam in a written form, in doubtful cases also in oral form. Possibility of passing the exam on the basis of two tests: one in the middle of the semester, the second at the end of the semester.

Classes in period "Summer semester 2023/24" (in progress)

Time span:	2024-02-19 - 2024-06-16	Selected timetable range: weekly course term Navigate to timetable MO TU WYK W TH FR
Type of class:	Lecture, 30 hours more information
Coordinators:	Renata Grzela
Group instructors:	Renata Grzela
Students list:	(inaccessible to you)
Examination:	Examination

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