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Bioinorganic Chemistry

General data

Course ID: 1200-1CHBNORWZ
Erasmus code / ISCED: 13.3 Kod klasyfikacyjny przedmiotu składa się z trzech do pięciu cyfr, przy czym trzy pierwsze oznaczają klasyfikację dziedziny wg. Listy kodów dziedzin obowiązującej w programie Socrates/Erasmus, czwarta (dotąd na ogół 0) – ewentualne uszczegółowienie informacji o dyscyplinie, piąta – stopień zaawansowania przedmiotu ustalony na podstawie roku studiów, dla którego przedmiot jest przeznaczony. / (0531) Chemistry The ISCED (International Standard Classification of Education) code has been designed by UNESCO.
Course title: Bioinorganic Chemistry
Name in Polish: Chemia bionieorganiczna
Organizational unit: Faculty of Chemistry
Course groups: (in Polish) Przedmioty do wyboru (dedykowane) dla studentów studiów 1-go stopnia - sem. zimowy
Course homepage: http://www.chem.uw.edu.pl/people/RBilewicz/
ECTS credit allocation (and other scores): 2.00 Basic information on ECTS credits allocation principles:
  • the annual hourly workload of the student’s work required to achieve the expected learning outcomes for a given stage is 1500-1800h, corresponding to 60 ECTS;
  • the student’s weekly hourly workload is 45 h;
  • 1 ECTS point corresponds to 25-30 hours of student work needed to achieve the assumed learning outcomes;
  • weekly student workload necessary to achieve the assumed learning outcomes allows to obtain 1.5 ECTS;
  • work required to pass the course, which has been assigned 3 ECTS, constitutes 10% of the semester student load.
Language: Polish
Type of course:

elective courses
Mode:

Blended learning
Short description:

To develop better understanding of structure - functionality relationship in biological and biomimetic processes involving inorganic molecules, metal ions and their biological complexes
Full description:

Metal ion complexes in biological systems. Types of metalloproteins: redox, hydrolytic, atom and group transfer enzymes. Activation and transport of dioxygen. Structure of the active site. Mechanism of reversible binding of dioxygen and cooperativity effects. Binding of carbon oxide to myoglobin and hemoglobin. Mechanism of biocatalyzed oxygen reduction. Overview of specific copper and iron enzymes, and their model compounds. Applications: biofuel cells and oxygen sensing. Biological nitrogen cycle: molybdenum-dependent nitrogen fixation, nitrification and denitrification processes. Nitrogenase - enzyme structure and mechanistic studies. Biologically relevant group transfer reactions. Reaction pathways involving cobalamins: vitamin and coenzyme B12. Model systems and role of apoenzyme. Metal ion uptake, transport in organisms and removal. Iron uptake by microorganisms: siderophores. Metal ion concentration gradients (ion-channels, voltage gated channels, ion pumps). Application of metal ion complexes in probing structure of nucleic acid. Medical applications of selected metal complexes: therapeutic compounds, diagnostic agents (MRI), and radionuclide complexes in nuclear medicine
Bibliography:

Notes from the lectures

For those who would like deeper insight:

Bioinorganic Chemistry R. M. Roat-Malone, Wiley 2007

Podstawy Chemii Bionieorganicznej S. Lippard, M.Berg, PWN 1998

Chemia Bioorganiczna P. Kafarski, B. Lejczak, PWN 1994

Biomolecular Films J.F.Rusling, M. Dekker 2003

(ask the lecturer)
Learning outcomes:

To learn the main problems and developing areas in bioinorganic chemistry and understand the importance of progress in the field for people, their health and environment
Assessment methods and assessment criteria:

Written or oral reply on a few questions connected with the program of lectures
Practical placement:

does not concern

Classes in period "Winter semester 2023/24" (past)

Time span: 2023-10-01 - 2024-01-28
Selected timetable range:
Navigate to timetable
Type of class:
Lecture, 30 hours, 50 places more information
Coordinators: Renata Bilewicz
Group instructors: Renata Bilewicz
Students list: (inaccessible to you)
Examination: Examination
Mode:

Blended learning

Classes in period "Winter semester 2024/25" (future)

Time span: 2024-10-01 - 2025-01-26
Selected timetable range:
Navigate to timetable
Type of class:
Lecture, 30 hours, 50 places more information
Coordinators: Renata Bilewicz
Group instructors: Renata Bilewicz
Students list: (inaccessible to you)
Examination: Examination
Mode:

Blended learning
Course descriptions are protected by copyright.
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