Biostereochemistry

obligatory courses

The student should have basic knowledge in the field of general and organic chemistry and biochemistry.

The lecture is a systematic introduction to static and dynamic stereochemistry of biomolecules. Intra and intermolecular interactions will be discussed as factors affecting the shape and dynamics of molecules. Then the lecture will cover geochemistry of peptides, proteins, nucleic acids and lipids, both in static and dynamic terms.

The lecture is a systematic introduction to stereochemistry of biomolecules and biomacromolecules. Intra and intermolecular interactions will be preliminarily discussed as factors affecting the shape and dynamics of molecules. Next, the lecture will cover the basic knowledge of general stereochemistry, discussing individual stereogenic elements determining the chirality of molecules and their aggregates. All concepts will be illustrated with examples from the current literature. Basic knowledge on supramolecular stereochemistry will also be introduced. Next, stereochemical issues will be discussed in relation to amino acids, peptides, proteins, nucleic acids, isoprenoids, polysaccharides and simple and complex lipids, both in terms of their static and dynamic stereochemistry. Protein dynamics research issues, both experimental and using computer modeling will also be discussed. The consequences of conformational changes in biomolecules in relation to their function in the body and in the drug design will be taken into account.

1. I. Z. Siemion, Biostereochemistry, PWN, Warsaw, 1986

2. E. L. Eliel, S. H. Wilen, L. N. Mander Stereochemistry of Organic Compounds J. Wiley&Sons, Inc., 1994

3. J. M. Berg, J. L. Tymoczko, L. Stryer, Biochemistry, 8th Edition, Palgrave, 2017

Knowledge of static and dynamic stereochemistry of biomolecules at an advanced level.

Written or oral exam in the form of personal contacts or on-line

Not applicable.