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Chemistry of Peptides and Proteins

General data

Course ID: 1200-2BLOK2W2
Erasmus code / ISCED: 13.3 Kod klasyfikacyjny przedmiotu składa się z trzech do pięciu cyfr, przy czym trzy pierwsze oznaczają klasyfikację dziedziny wg. Listy kodów dziedzin obowiązującej w programie Socrates/Erasmus, czwarta (dotąd na ogół 0) – ewentualne uszczegółowienie informacji o dyscyplinie, piąta – stopień zaawansowania przedmiotu ustalony na podstawie roku studiów, dla którego przedmiot jest przeznaczony. / (0531) Chemistry The ISCED (International Standard Classification of Education) code has been designed by UNESCO.
Course title: Chemistry of Peptides and Proteins
Name in Polish: Chemia peptydów i białek
Organizational unit: Faculty of Chemistry
Course groups: (in Polish) Chemia biomolekuł (S2-CH)
ECTS credit allocation (and other scores): 3.00 Basic information on ECTS credits allocation principles:
  • the annual hourly workload of the student’s work required to achieve the expected learning outcomes for a given stage is 1500-1800h, corresponding to 60 ECTS;
  • the student’s weekly hourly workload is 45 h;
  • 1 ECTS point corresponds to 25-30 hours of student work needed to achieve the assumed learning outcomes;
  • weekly student workload necessary to achieve the assumed learning outcomes allows to obtain 1.5 ECTS;
  • work required to pass the course, which has been assigned 3 ECTS, constitutes 10% of the semester student load.
view allocation of credits
Language: Polish
Main fields of studies for MISMaP:

chemistry
Type of course:

obligatory courses
Prerequisites (description):

Students should be familiar with basic organic chemistry with special general consideration of amino acids, peptides and protein structures.
Mode:

Classroom
Short description:

The aim of this course is to introduce to students issues associated with structure and biological activity of peptides and proteins. In detailes peptide synthesis (in solution and on solid support), synthesis of peptidomimetics and structure activity relationship of biologically active peptides will be presented.
Full description:

The following issues will be presented during the course:

1. Historical outline of peptide synthesis

2. Natural amino acids: occurrence and properties

3. Structure and biological acitivity of selected biologically active peptides

4. Peptide synthesis: protecting groups used in peptide chemistry (amino, carboxy , hydroxylic, or tiol function)

5. Peptides synthesis: condensation reaction (methods and reactants)

6. Peptide synthesis in solution and on the polymeric support

7. Problem of racemisation

8. Peptide purification and analysis (HPLC, MS, 2D NMR)

9. Structure-activity relationship of biologically active peptides

10. Drug design: From natural peptides to drugs (peptidomimetics)

11. Peptide drugs

12. Combinatorial peptide synthesis

13. Proteins: classification, levels of protein structure, receptors

14. Application of peptides and proteins in physicochemical research
Bibliography:

Peptides: chemistry and biology, Sewald N., Jakubke HD., Viley-VCH, 2002

Naturalne związki organiczne, Kołodziejczyk A., PWN, 2005

Aminokwasy, peptydy i białka, Jakubke HD., Jeschkeit H., PWN, 1989

Introduction to Medicinal Chemistry, Patrick G. Oxford University Press 2005
Learning outcomes:

After finishing this course student should be familiar with the basic concept of peptide synthesis, including stategy and tactic of peptide synthesis for different applications of synthetic peptides.

It should also have the ability to define common research objectives of those involved in the research of biological, biochemical and physicochemical properties of peptides and proteins.
Assessment methods and assessment criteria:

Exam.

Practical placement:

Does not concern

Classes in period "Winter semester 2023/24" (past)

Time span: 2023-10-01 - 2024-01-28
Selected timetable range:
Navigate to timetable
Type of class:
Lecture, 30 hours, 30 places more information
Coordinators: Aleksandra Misicka-Kęsik, Dagmara Tymecka
Group instructors: Aleksandra Misicka-Kęsik, Dagmara Tymecka
Students list: (inaccessible to you)
Examination: Examination
Course descriptions are protected by copyright.
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