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Advanced Synthesis of Pharmaceutical Substances

General data

Course ID:	1200-2CHMMO1W3
Erasmus code / ISCED:	13.3 Kod klasyfikacyjny przedmiotu składa się z trzech do pięciu cyfr, przy czym trzy pierwsze oznaczają klasyfikację dziedziny wg. Listy kodów dziedzin obowiązującej w programie Socrates/Erasmus, czwarta (dotąd na ogół 0) – ewentualne uszczegółowienie informacji o dyscyplinie, piąta – stopień zaawansowania przedmiotu ustalony na podstawie roku studiów, dla którego przedmiot jest przeznaczony. / (0531) Chemistry The ISCED (International Standard Classification of Education) code has been designed by UNESCO.
Course title:	Advanced Synthesis of Pharmaceutical Substances
Name in Polish:	Zaawansowana synteza leków
Organizational unit:	Faculty of Chemistry
Course groups:	(in Polish) Moduł 1 Leki - od projektowania do wdrożenia (S2-PRK-CHM)
ECTS credit allocation (and other scores):	1.50 Basic information on ECTS credits allocation principles: the annual hourly workload of the student’s work required to achieve the expected learning outcomes for a given stage is 1500-1800h, corresponding to 60 ECTS; the student’s weekly hourly workload is 45 h; 1 ECTS point corresponds to 25-30 hours of student work needed to achieve the assumed learning outcomes; weekly student workload necessary to achieve the assumed learning outcomes allows to obtain 1.5 ECTS; work required to pass the course, which has been assigned 3 ECTS, constitutes 10% of the semester student load. view allocation of credits
Language:	Polish
Type of course:	obligatory courses
Mode:	Classroom
Short description:	The subject of the lecture is the outline of modern medical chemistry of low molecular weight active substances of drugs from the group of nucleosides acting against the SARS-CoV-2 virus. Methods of designing and obtaining antiviral nucleosides will be presented. The study of the biological activity of antiviral substances and the optimization of their structure will be discussed. The mechanisms of the antiviral activity of nucleoside compounds will be elucidated. The concept of PROTIDE prodrug in this group of compounds will be presented.
Full description:	The subject of the lecture is to present the outline of modern medical chemistry of low molecular weight active substances of drugs from the group of nucleosides with activity against the SARS-CoV-2 virus. In the lecture block, methods of designing and obtaining such antiviral nucleosides as remdesivir, molnupiravir, favipiravir, galidesivir, Paxlovid and lufotrelvir will be presented. The study of biological activity of antiviral substances and optimization of their structure will be presented. The mechanisms of the antiviral activity of nucleoside compounds will be elucidated. The concept of a prodrug (PROTIDE) will be presented. The lecture is illustrated with materials from publications from leading research centers in generally available Open Access journals (no textbooks are available for the lecture). All the lecture material will be presented on slides and short videos and entirely available to the lecture attendees.
Bibliography:	Open Access 2-3 publications from the leading scientific journals presented at each lecture.
Learning outcomes:	Understanding modern methods of advanced medical chemistry on the example of designing and obtaining active substances of drugs against the SARS-CoV-2 virus. Acquiring the ability to perform retrosynthetic analysis and design a general scheme for the synthesis of antiviral nucleosides. Understanding the mechanisms of action of antiviral drugs at the molecular level.
Assessment methods and assessment criteria:	Final written exam on the lecture material. Answering 15 questions within 1.5 hours. in the form of a description or a scheme of synthesis.

Classes in period "Summer semester 2023/24" (in progress)

Time span:	2024-02-19 - 2024-06-16	Selected timetable range: weekly course term Navigate to timetable MO TU WYK W TH FR
Type of class:	Lecture, 15 hours more information
Coordinators:	Andrzej Kutner
Group instructors:	Andrzej Kutner
Students list:	(inaccessible to you)
Examination:	Examination

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