Specialization Laboratory - Organic Chemistry and Chemical Technology

chemistry

obligatory courses

The student should have a credit from organic chemistry IA, chemical technology and biochemistry.

Classroom

The programme of classes includes theoretical and practical familiarization of students with the scientific topics of the research group in the Department of Organic Chemistry and Chemical Technology in order to better prepare the students for the implementation of the master's thesis.

The topics of specialization exercises are related to the subject of research conducted in the research laboratories of ZChOiTCh. Within the specialization laboratory, students perform selected exercises from the proposed list of topics, including at least one exercise in English.

- Związki organiczne ulegające samoorganizacji - synteza i charakterystyka mezogenów.

- Synteza, oczyszczanie i właściwości fizykochemiczne organicznych półprzewodników.

- Analiza termiczna w chemii materiałów funkcjonalnych.

- Pomiar wielkości i stabilności nanocząstek metodą Dynamicznego Rozpraszania Światła (DLS).

- Synteza prekursora (w reaktorze wysokociśnieniowym) do wytwarzania pianek poliuretanowych. Analiza mieszaniny poreakcyjnej.

- Polimeryzacja rodnikowa kontrolowana rodnikami nitroksylowymi.

- Synteza nowych materiałów z zastosowaniem polimeryzacji ATRP.

- Otrzymywanie katalizatora do reakcji metatezy olefin typu Hoveydy-Grubbsa:

kompleksu dichloro[1,3-bis(2,4,6-trimetylofenylo)-4,5-dihydroimidazol-2-ylideno[2-(i-propoksy)-5-nitrofenylo]metylideno]rutenu(II).

- Otrzymywanie katalizatora do reakcji metatezy olefin typu Hoveydy-Grubbsa:

kompleksu dichloro[1,3-bis(2,6-di{2-propylo}fenylo)-4,5-dihydroimidazol-2-ylideno[2-(i-propoksy)-5-nitrofenylo]metylideno]rutenu(II).

- Ozonoliza fenantrenu.

- Kataliza asymetryczna wspomagana wysokim ciśnieniem.

- Asymetryczna synteza organiczna z użyciem chiralnych katalizatorów.

- Wyznaczanie parametrów kinetycznych w reakcjach enzymatycznych metodami polarymetrycznymi.

- Zastosowanie promieniowania mikrofalowego w syntezie organicznej.

- Elektroforeza białek w żelu poliakryloamidowym.

- Izolacja i charakterystyka DNA.

- Synteza peptydów na nośniku polimerycznym.

- Chemia "klik" - synteza związku fluorescencyjnego.

- Synteza i post-syntetyczna modyfikacja materiałów typu MOF (Metal-Organic Framework).

- "Click" chemistry - synthesis of a fluorescent compound.

- Organic chemistry tools for synthesis and purification of a drug delivery system.

- Organic chemistry tools for synthesis and physicochemical characteristic of a drug delivery system.

- Synthesis, purification and physicochemical properties of organic semiconductors.

- Thermal analysis of functional materials.

- Determination of size and stability of nanoparticles by DLS method.

- Dynamic Light Scattering application in size detection of molecules and molecular aggregates.

- Nitroxide mediated polymerization.

- Atom transfer radical polymerization (ATRP) in preparation of new materials.

- Preparation of the Hoveyda-Grubbs-type catalyst for the olefin metathesis reaction:

[1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene]-dichloro-[(5-nitro-2-propan-2-yloxyphenyl)methylidene]ruthenium(II) complex.

- Ozonolysis of phenantren.

- Asymmetric organic synthesis with a chiral catalyst.

- Determination of kinetic parameters in enzymatic reactions by polarimetric methods.

- Application of microwave radiation in organic synthesis.

- Protein electrophoresis in polyacrylamide gel.

- DNA isolation and characterization.

Literature appropriate to the topic of the exercise, given by the teacher.

After completing the course student:

- uses modern methods of synthesis of organic compounds, nanoparticles, compounds with liquid crystalline properties, polymers, chiral catalysts, coordination compounds, including the use of microwaves, Schlenk technique, high-pressure reactors,

- uses modern research and analytical techniques such as: GC chromatography, HPLC, thermal analysis (DSC, TG), dynamic light scattering method (DLS), UV-Vis spectrophotometry, spectrofluorimetry, polarimetry, SAXS, SAXD, POM, 1H NMR, FTIR spectroscopy,

- knows the principles of occupational safety and health in a chemical laboratory,

- works in a team and is aware of responsibility for jointly accomplished tasks related to teamwork.

Attendance mandatory. The number of excused absences allowed is 3 classes.

Assessment from the laboratory is the arithmetic mean of assessments from the exercises performed.

Not applicable.