Print syllabusGPCRs – structures, actions, drugs
General data
| Course ID: | 1200-2MON41L |
| Erasmus code / ISCED: |
13.3
|
| Course title: | GPCRs – structures, actions, drugs |
| Name in Polish: | Receptory GPCR - struktury, działanie, leki |
| Organizational unit: | Faculty of Chemistry |
| Course groups: |
(in Polish) Przedmioty do wyboru w semestrze 3M (S2-PRK-CHM) (in Polish) Wykłady monograficzne (S2-CH, S2-CHS) (in Polish) Wykłady monograficzne w semestrze letnim (S2-CH, S2-CHS) |
| ECTS credit allocation (and other scores): |
1.50
|
| Language: | Polish |
| Main fields of studies for MISMaP: | biology |
| Type of course: | elective monographs |
| Prerequisites (description): | Knowledge of basic topics from biochemistry. |
| Mode: | Classroom |
| Short description: |
Introduction to G-protein-coupled receptors (GPCRs) which are responsible for communications between cells (neuronal and hormonal signaling) and with external world (seeing, taste, smell). Overview of their structures, activation mechanisms and cell signaling, as well as the action of drugs on these receptors in various diseases. |
| Full description: |
GPCRs form a very large family of membranous transmitters of signals consisting of about 800 of various types of these receptors. Despite of participating in completely different signaling cascades which are influencing divergent cell processes their structures are uniform and consist of seven transmembrane helices. GPCRs are activated by enormous number of various ligands from photons and ions up to lipids, neurotransmitters, hormones, and small proteins. Because GPCRs pursue most of cell signaling they participate in many physiological and pathological processes and are molecular targets for 30%-50% of all currently used drugs. In the lecture the structures of known complexes of GPCR-ligand (blocking or activating the receptor) as well as activation and signaling mechanisms on molecular and atomic levels will be shown. Also the connections of GPCRs with various diseases will be described. The following receptors will be presented among others: adrenergic receptors (adrenaline, cardiac and antiasthmatic drugs), dopamine receptors (dopamine, lack in Parkinson’s disease), 5-HT receptors (serotonin, LSD), muscarinic receptors (acetylcholine, lack in Alzheimer’s disease), opioid receptors (morphine and analgesics), cannabinoid receptors (anadamide, THC), histamine receptors (histamine and anti-allergic drugs). Since GPCRs are molecular targets for “popular” hormones: acetylcholine (memory, learning), dopamine (love, passions), serotonin (happiness, satisfaction) they have their place in pop culture. These receptors are also targets for many narcotics. The structure of the first GPCR, rhodopsin, was determined only in 2000, and since then the interests in studying of GPCRs and substances they bind increased greatly. |
| Bibliography: |
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| Learning outcomes: |
Knowing of main types of GPCRs, division of GPCR family by their structure, kinds of drug-receptor interactions, and activation and signaling mechanisms of these receptors. Knowing of some pathological processes involving GPCRs and ways of treatment by using suitable drugs. |
| Assessment methods and assessment criteria: |
Requirements related to participation in class - none. Permitted number of justified absences - 50%. Test exam with 50% of closed questions and 50% of open questions - the same for correction test. Required minimum 50% of correct answers to pass. |
| Practical placement: |
N/A |
Classes in period "Summer semester 2023/24" (in progress)
| Time span: | 2024-02-19 - 2024-06-16 |
 
MO WYK-MON
TU W TH FR |
| Type of class: |
Monographic lecture, 15 hours, 30 places
|
|
| Coordinators: | Sławomir Filipek | |
| Group instructors: | Sławomir Filipek | |
| Students list: | (inaccessible to you) | |
| Examination: | Grading |
Copyright by University of Warsaw.
