Autoxidation and Antioxidants

General data

Course ID:	1200-2MON45L
Erasmus code / ISCED:	13.3 Kod klasyfikacyjny przedmiotu składa się z trzech do pięciu cyfr, przy czym trzy pierwsze oznaczają klasyfikację dziedziny wg. Listy kodów dziedzin obowiązującej w programie Socrates/Erasmus, czwarta (dotąd na ogół 0) – ewentualne uszczegółowienie informacji o dyscyplinie, piąta – stopień zaawansowania przedmiotu ustalony na podstawie roku studiów, dla którego przedmiot jest przeznaczony. / (0531) Chemistry The ISCED (International Standard Classification of Education) code has been designed by UNESCO.
Course title:	Autoxidation and Antioxidants
Name in Polish:	Autoxidation and Antioxidants
Organizational unit:	Faculty of Chemistry
Course groups:	(in Polish) Wykłady monograficzne w semestrze letnim (S2-CH, S2-CHS)
ECTS credit allocation (and other scores):	(not available) Basic information on ECTS credits allocation principles: the annual hourly workload of the student’s work required to achieve the expected learning outcomes for a given stage is 1500-1800h, corresponding to 60 ECTS; the student’s weekly hourly workload is 45 h; 1 ECTS point corresponds to 25-30 hours of student work needed to achieve the assumed learning outcomes; weekly student workload necessary to achieve the assumed learning outcomes allows to obtain 1.5 ECTS; work required to pass the course, which has been assigned 3 ECTS, constitutes 10% of the semester student load. view allocation of credits
Language:	English
Type of course:	elective monographs
Mode:	Classroom
Short description:	Principles of free radical processes. Formation and detection of free radicals, their stability and reactivity. Kinetics of radical mediated processes. Chain reactions. Radicals and quasi-radicals containing oxygen. Basic lipid chemistry – role of lipids, their classification and sensitivity toward hydrogen atom abstraction processes. Structure of cell membranes and oxidative damage of lipids / phospholipid bilayers. Kinetics of autoxidation – rates of mono and polyunsaturated fatty acid oxidation. Photooxidation and enzymatic autoxidation. Preventive antioxidants – enzymes, complexing agents, singlet oxygen quenchers. Chain-breaking antioxidants and retarders. Ascorbic acid, carotenoids, tocopherols, flavonoids. Synergism in antioxidant action. Tocopherol mediated peroxidation.
Full description:	Principles of free radical processes. Formation and detection of free radicals, their stability and reactivity. Kinetics of radical mediated processes. Chain reactions. Radicals and quasi-radicals containing oxygen. Basic lipid chemistry – role of lipids, their classification and sensitivity toward hydrogen atom abstraction processes. Structure of cell membranes and oxidative damage of lipids / phospholipid bilayers. Kinetics of autoxidation – rates of mono and polyunsaturated fatty acid oxidation. Photooxidation and enzymatic autoxidation. Preventive antioxidants – enzymes, complexing agents, singlet oxygen quenchers. Chain-breaking antioxidants and retarders. Ascorbic acid, carotenoids, tocopherols, flavonoids. Synergism in antioxidant action. Tocopherol mediated peroxidation.
Bibliography:	Grzegorz Bartosz: Druga twarz tlenu, PWN, Warszawa, 2006 B. Halliwell, J. Gutteridge: Free Radicals in Biology and Medicine, 4th edition, Oxford University Press, 2007 J. Perkins: Radical Chemistry, Ellis Horwood, London, 1994 L. Packer, J. Fuchs (Eds): Vitamin E in health and disease, Marcel Dekker Inc. New York 1992 R. A. Larson: Naturally occurring antioxidants. CRC Press, Boca Raton -New York, 1997 Cadenas E., Packer L. (Eds.): Handbook of antioxidants, Marcel Dekker, New York, 1996 Afanas'ev I. B.: Superoxide ion: Chemistry and biological implications. vol. 1-II, CRC Press, Boca Raton, 1989
Learning outcomes:	During this course the students will get knowledge about mechanism of lipid oxidation, kinds of free radicals and free radical precursors, methods of investigation of peroxidation processes, classes of substances preventing and retarding autoxidation. The students will get ability to study research literature on autoxidation chemistry.
Assessment methods and assessment criteria:	examination
Practical placement:	N/A

This course is not currently offered.

Course descriptions are protected by copyright.
Copyright by University of Warsaw.