Chemistry of Heterocyclic Compounds

elective courses

Organic Chemistry I 1200-1CHOR1W3

Organic chemistry I

Classroom

This lecture provides a concise overview of the main principles and reactions of heterocyclic chemistry.

This lecture covers the following topics:

- Three-membered rings with oxygen, nitrogen and sulphur; biological activity (pheromones, anti-cancer drugs), synthesis and reactivity;

- Four-membered rings; synthesis and reactivity; beta-lactam antibiotics

- Fife-membered rings (furans, pyroles, thiophenes); synthesis; utilization in drug synthesis;

- Six-membered rings (pyridines, pyranes); synthesis and reactivity (electrophilic and nucleophilic substitution); utilization in alkaloid synthesis;

- Quinolines, isoquinolines, indoles; occurrence in the nature; utilization in synthesis of dyestuffs and drugs;

- Application of heterocyclic compounds in organic synthesis;

- Heterocyclic compounds in new technologies;

1. Heterocyclic Chemistry, John A. Joule, Keith Mills, A John Wiley & Sons, Ltd.,

Publication;

2. I. Młochowski, Chemia związków heterocyklicznych, PWN

3. T. Eichler, S. Hauptmann, Wiley-VCH, Weinheim, The Chemistry of

Heterocycles;

4. Julio Alvarez-Builla, Juan Jose Vaquero, and José Barluenga, Modern

Heterocyclic Chemistry Volume 4;

5. John A. Joule, Keith Mills, Heterocyclic Chemistry at a Glance, Blackwell

Publishing;

6. Stephen Po Stanforth, Natural Product Chemistry at a Glance, Blackwell

Publishing;

Students will acquire knowledge encompassing synthesis, reactivity and biological activity of chosen heterocyclic compounds.

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