Pathogenesis of parasitic diseases

biology
biotechnology

obligatory courses

Animal Physiology M 1400-124FZ-M
Cell Biology M 1400-112BK-M
Parasitology - Lecture 1400-215PARAZ-W

Animal and Human Physiology D 1400-114FZ
Cell Biology 1400-112BK
Cell biology and histology 1100-1BO16
Immunology 1400-216IMM
Immunology 1400-216IMM-W
Immunoparasitology 1400-225IMMP
Immunoparasitology - W 1400-225IMMP-W
Microbiology - W 1400-113MIK-W

During the course a knowledge of pathogenesis evoked by parasitic species will be given; biology of infection and molecular processes will be the subject. Students will know and understand the outcome of parasite pathogenicity and host immune response which are useful for molecular diagnosis of parasitic infection in men. The aim of the course is also to provide a knowledge about epidemiology of parasitic diseases, therapy and anti-parasitic control.

Classroom

From parasite infection to parasitic disease: host-parasite interaction at the molecular level, between organisms and between species during infection with Protista and helminthes. Molecular markers for pathogenicity of parasitic Protista and helminthes Molecular mechanism of blood parasite transmission by arthropod vectors. Genetic epidemiology of parasitic infections related to anti-parasitic response with different outcome of disease. Control of parasitic diseases emergency.

Parasitic diseases:

- Tropical diseases: malaria, trypanosomiasis, schistosomiasis, filariasis

- Geohelminthes infection: ascaridiasis, hookworm diseases, whipworm

- Parasitic Protista: Cryptosporidium parveum, Giardia intestinalis, Entamoeba sp. Naegleria sp., Acanthamoeba sp.

- Zoonotic disease: Toxoplasma gondii, tapeworm, echinococcus, Trichinella spiralis, Toxocara canis.

Lecture 1. Parasitism, parasitic diseases, pathogenecity, pathology, virulence, epidemiology.

Lecture 2. Tropical diseases; Leishmaniosis

Lecture 3. Tropical diseases; Malaria. Biology and pathology of Plasmodium falciparum, P. vivax, P. ovale, P. malariae, P. knowlesi infections.

Lecture 4. Tropical diseases; Malaria. Physiological and molecular determinants of malaria symptoms. Immunologic and genomic data for vaccine preparation.

Lecture 5. Tropical diseases: Trypanosomiasis. Biology and epidemiology of Trypanosoma brucei rhodesiense, T. b. gambiense i T. cruzii infections. Genomic data for vaccination.

Lecture 6.Tropical diseases; Schitsosomiasis. Immune response to parasite. Evoking of immune recognition. Drug resistance to Praziquantel. Antigens of larvae and adult fluks in vaccine.

Lecture 7. Filariosis. Molecular markers for epidemiological monitoring of disease. Biology of Onchocerca volvulus, Wuchereria bancrofti, Brugia malayi infections. Pathogenesis predicted from endosymbiotic riketsia.

Lecture 8. Water and soil - borne infections. Biology of Entamoeba histolytica, Naeglaria flowleri, Acanthamoeba castellani infections. Mucosal immune rosponse to pathogens.

Lecture 9. Water and soil - borne infections. Biology of Giardia, Cryptosporidium, Tritrichomonas infections. Immunology of infection in immunocompromised patients.

Lecture 10. Soil -transmited helmintic infections. Intestinal nematodes. Inflammation. Complement. Allergy. Eosinophil response. Mechanism of protection and resistance.

Lecture 11. Soil transmited helmintic infections - Ascarids. Trichuris. Immunoregulation. Pathology induced by migrating larvae. Drug resistance in nematodes. Helminthotherapy

Lecture 12. Hookworms. Biology and immunology of Necator americanus and Ancylostoma duodenale infections. Immunoregulation. Pathology related to migratory larva. Antigens for vaccination.

Lecture 13. Zoonosis. Biology and immunology of Toxoplasma infection. The risk factors of infection during pregnancy. Apicoplast as a target for drug treatment.

Lecture 14. Zoonotic infections: Echinococcosis, trichinellosis, toxocarosis. Molecular diagnosis of infection. Visceral larvae migrans, ocular larvae migrans.

Lecture 15. MHC polimorphism and immunity. Genetic background of antiparasitic resistance.

Smyth J.D. Introduction to animal parasitology. Cambridge University Press. ed III.

Mehlhorn H. (ed.) (1988) Parasitology in Focus Springer-Verlag.

Roberts et al. ed. (2013). Gerald D. Smith and Lary S.Roberts Foundations of Parasitology. McGraw-Hill International.

Deryło A. (red.) (2011) Parazytologia i akaroentomologia medyczna. Wydawnictwo Naukowe PWN.

Kadłubowski R. i Kurnatowska A. (red). 2001. Zarys parazytologii lekarskiej. Wydawnictwo lekarskie PZWL.

Pawłowski Z.S. i Stefaniak J (red). (2004) Parazytologia kliniczna w ujęciu wielodyscyplinarnym. Wydawnictwo lekarskie PZWL.

Trends in Parasitology (Elsevier)

Trends in Immunology (Elsevier)

Trends in Microbiology (Elsevier)

KNOWLEDGE

Student will know the epidemiology of parasitic diseases and understand the reasons and mechanisms of expansion of parasitic invasions, host immunology and genetic of parasites [K_W01B2; K_W02_BTM; K_W03_BTM; K_W12_BTM; K_K06_BTM];

Student is able to identify and discuss molecular processes of pathology causing by parasites [K_W06_B2; K_W02_BTM; K_W03BTM; K_W12BTM; K_K06BTM];

Student is able to select the particular molecular process that could be used in anti-parasite therapies [K_W01B2; K_W03BTM; KU_03BTM].

Student is able to critically evaluate the pathogenic diversity of parasites and human susceptibility to parasitic invasions [K_W06B2; K_W02BTM; K_W03BTM; K_U03BTM; K_K02BTM].

Student knows biology of human pathogens and can characterize the diseases caused by these pathogens [K_W07BT1; K_W02B2; K_W02BTM; K_W03BTM; K_W12BTM; K_K06BTM];

Student knows molecular markers used in epidemiological and genetic studies, immunological mechanisms and parasite molecules which regulate the host immune response [K_W02BTM; K_W03BTM; K_W12BTM; K_U03BTM; K_K02BTM; K_K06BTM; K_K11BTM].

Student understands molecular mechanisms of vaccine development against parasites and knows the phenomenon used in studies of anti-parasitic therapies [K_09BT1; K_W14B2; K_W18B2; K_W02BTM; K_W03BTM; K_W05BTM; K_K06BTM; K_K11BTM].

SKILLS

Student can interpret the phenomenon of parasitism at molecular and individual interactions in population and ecosystem; analyses data of parasite biology in relation to epidemiology of parasitic diseases [K_U01BI1,K_U01BI2, K_U04BI1

Student uses and understands scientific language and parasitological terminology, gets data from electronical sources and scienific publications [K_U03BI1, K_U03BI2]

Student can critically evaluate the public information concerning the risk of infection with parasites [K_U04BI1, K_U04BI2, , K_U09BI2]

Is prepared to plan his own professional career using parasitological knowledge [K_U10BI1, K_U13BI2]

He knows how to dealing with risk factor of parasitic infections [K_U12BT2]

SOCIO-COMPETENCE

Student expends owns knowledge of parasitology interests in medicine and veterinary [K_K01BI1, K_K01BI2 K-K03BI1]

Student understands and can clearly explain new information in parasitology and feel to be responsible for his informative activities in society [K_K03BI1, K_K03BI1, K_K04BI1, K_K02BI2, K_K03BI2, K_K11BI2]

Student is cautious and critical in evaluation of public information concerning the risk factors of infection with parasites. Students understands the need to improve and develop his professional career and skills [K_K06BI1, K_K08BI1, K_K10BI2, K_K07BI2]

Examination: full exam has 25 questions of multiply choice and 5 open questions. 60% of positive answers pass mark.

not aplicable